Toilet water could more accurately be described as swirled rather than shaken or stirred. What really bothered me was Ralph's water bowl. The water appears to be a dome in the middle of the bowl. Is there any physical way that could happen, at least to that extent? Sometimes we all get caught up in the details I guess.
Runners-up: Blondie, Dennis the Menace, Family Circus, For Better or For Worse, Frank and Ernest, Garfield, Hagar the Horrible
The snake's expressions sealed this one.
Runners-up: Frazz, Get Fuzzy, Pearls Before Swine, Pooch Cafe, Watch Your Head, Zits