I am really starting to loathe Hagar the Horrible. It presents a completely bleak picture of marriage, it bends the setting and characters for bad jokes. The first problem with this strip is Helga's unhealthy approach to marital problems. Josh Fruhlinger, of the Comics Curmudgeon, had a great take on this strip. He points out the second problem, which is the poor art. Hagar is absolutely weird looking.
Runners-up: Baldo, Close to Home, Frank and Ernest, Mother Goose and Grimm, Red and Rover, Rhymes with Orange, Speed Bump
I loved this strip.
Runners-up: Agnes, Brewster Rockit: Space Guy!, Frazz, Get Fuzzy, Lio, Pearls Before Swine, Sherman's Lagoon, Zits