I absolutely do not get this. Is there some ad campaign for V8 that involves people getting bonked on the head? Even if there is, the set-up is very awkward. I don't think I've ever heard someone say that someone else bonked them on the head.
Runners-up: Beetle Bailey, Curtis, Garfield, Rhymes with Orange, Speed Bump
I want to be a professional imaginer. I like how Agnes' Grandmother just rolls with the punches.
Runners-up: Brewster Rockit: Space Guy!, Frazz, Get Fuzzy, Pearls Before Swine, Piranha Club (I'm really enjoying this escape attempt series in spite of myself), Sally Forth, Watch Your Head (Cory Thomas does a nice job of shading in some back story)