Dagwood is from a rich family and has a white-collar job. Does anyone like that actually bowl? Maybe in the 1950's, but it seems pretty unlikely here in 2008. It's an awful lot of set-up for a bowling joke.
Runners-up: Argyle Sweater, Family Circus, Garfield, Hagar the Horrible, Prickly City, Rhymes with Orange, Sherman's Lagoon, Zits
Andy exists purely to create pathos, I enjoy it.
Runners-up: Agnes, Baldo, Brewster Rockit: Space Guy!, Cul de Sac (based on Dil's line in the last panel), Dilbert, Get Fuzzy