So we have a nagging mother-in-law who attacks through he daughter, a wife who takes her mother's criticism and uses it as a reason to nag her husband, an alcoholic husband who would rather drink than be with his family, and a relationship with no healthy, viable communication. What fun.
Runners-up: Baldo, Beetle Bailey, Blondie, Close to Home, Daddy's Home, Dennis the Menace, Family Circus, For Better or For Worse, Frank and Ernest, Garfield, Mother Goose and Grimm, Prickly City, Red and Rover, Rhymes with Orange, Speed Bump
Agnes' bizarreness was enough to win on a fairly weak day.
Runners-up: Lio, Mutts, Pooch Cafe, Single and Looking