I hate Rhymes with Orange. The art is terrible and it's not redeemed by the jokes.
Runners-up: Curtis, Dilbert, Family Circus, Frank and Ernest, Garfield, Mother Goose and Grimm
I enjoyed this send up of a comic strip convention.
Runners-up: Agnes, Big Nate, Brewster Rockit: Space Guy!, Doonesbury, Mutts, Zits