Worst: The biggest problem with this strip is that comics are rarely funny. Most get mileage from being cute. Some mine the truths of life to elicit smiles. Most are not funny, and I laugh at a comic once every couple of weeks. The set-up is awkward too, especially the fourth panel.
Runners-up: Blondie, Candorville, Dilbert, Family Circus, Garfield, Hagar the Horrible
If I ever find an eyeball in my smoothie, I am definitely making a wish.
Runners-up: Agnes, Cul de Sac, Doonesbury, For Better or For Worse, Lio, Pearls Before Swine, Prickly City, Sherman's Lagoon