Worst: I'm still not sure I get this joke. I assume it has something to do with people finding cockroaches repulsive. I also think the dialogue is kind of sexist.
Runners-up: Baldo, Blondie, Brevity (once again, substituting random for clever), Family Circus, Garfield, Hagar the Horrible, Rhymes with Orange
Runners-up: Agnes, Pickles