Runners-up: Dennis the Menace, Family Circus, For Better or For Worse, Garfield, Hagar the Horrible, Mutts, Red and Rover, Rhymes with Orange, Speed Bump
Cheese is a wonderful gift from God, it's in Job somewhere I think. In addition to being a paean to cheese and to Agnes' wonderful lack of a clue, Tony Cochran makes an interesting point in this series. I have absolutely no idea what the steps are between milking the cow and eating the cheese.
Runners-up: Frank and Ernest, Frazz, Get Fuzzy, Lio, Pearls Before Swine, Pickles, Pooch Cafe, Watch Your Head, Zits