Worst: All the white space makes this very unappealing visually. Couldn't they have drawn some trees or bushes or something to break it up? And the joke isn't good either.
Runners-up: For Better or For Worse, Mother Goose and Grimm, Brewster Rockit: Space Guy!, Garfield
Best: This might be the upset of the year. I normally hate Brevity (and all the one panel comics for that matter). This one made me smile though. It's cute, it's a little funny, and it makes sense, any one of those would make this better than normal for Guy & Rodd, but all three make it a winner.
Runners-up: Get Fuzzy, Prickly City, Candorville, Pooch Cafe, Baby Blues