Worst: The set-up for this joke is terrible. I can't imagine anyone ever speaking the dialogue Hagar speaks in the first panel. And no one would ever tell their wife that they were flirting with a cute girl, except in some sort of anxious confession. I guess it fits because Hagar is supposed to be rude, but really, this joke fails on a lot of levels.
Runners-up: Close to Home, Red and Rover, Prickly City (Republicans are pure and virtuous, and Democrats are evil, I get it already), Mother Goose and Grimm (another bad joke with an awkward set-up)
Best: First, I enjoy the thought of a bewildered flamingo conservancy, so the baseline of humor in this strip is high. I like that Agnes fraternizes with some random drunk guy. I like Agnes' complete lack of a clue. I like Trout's complete lack of surprise at Agnes' lack of a clue.
Runner-up: Baby Blues