Runners-up: Baldo (for the visual in the last panel), Close to Home, Dennis the Menace, For Better or For Worse, Garfield, Red and Rover, Rhymes with Orange
Note what isn't present in the runners-up.
Runners-up: Frank and Ernest, Get Fuzzy, Pearls Before Swine, Tank McNamara, Watch Your Head, Zits
Comics Note: Self-indulgent crap like this is exactly why I dislike For Better or For Worse. Ellie and Connie chose to have kids and they act like they deserve a medal. Yes it's hard work raising kids, but it's hard work being a major league baseball player, or a UN delegate, or a trash collector, or any job really. So why do we privilege motherhood and family so highly? Perpetuation of the status quo, problems included, is not a heroic act.